THE GREATEST GUIDE TO PKRRATING

The interfacial residues are really conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations support a product where by activating RNA serves to be a scaffold to bind multiple PKR monomers, escalatin

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